p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong Hyuk | - |
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Kim, Ho Hyun | - |
dc.contributor.author | Bang, Joon Seok | - |
dc.contributor.author | Jung, Tae Woo | - |
dc.contributor.author | Park, Taekwang | - |
dc.contributor.author | Park, Jinwoo | - |
dc.contributor.author | Kim, Uiseok | - |
dc.contributor.author | Lee, Sung Hoon | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.date.available | 2021-02-22T07:46:27Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4180 | - |
dc.description.abstract | The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2'-deoxyuridine-positive cells relative to total proliferative cells. Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. These results suggest that p-coumaric acid has the potential to increase height and may be a feasible alternative to growth hormone therapy. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.10.046 | - |
dc.identifier.scopusid | 2-s2.0-85056044827 | - |
dc.identifier.wosid | 000450019400024 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.505, no.4, pp 1103 - 1106 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 505 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1103 | - |
dc.citation.endPage | 1106 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | HYDROXYCINNAMIC ACID | - |
dc.subject.keywordPlus | FEMORAL TISSUES | - |
dc.subject.keywordPlus | CAFFEIC ACID | - |
dc.subject.keywordAuthor | P-coumaric acid | - |
dc.subject.keywordAuthor | Tibial length | - |
dc.subject.keywordAuthor | Growth plate | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Insulin-like growth factor | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0006291X18321922?via%3Dihub | - |
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