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Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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dc.contributor.authorKim, Seong-Min-
dc.contributor.authorLee, Seyeong-
dc.contributor.authorKim, Dongyoon-
dc.contributor.authorKang, Dong-Hee-
dc.contributor.authorYang, Kisuk-
dc.contributor.authorCho, Seung-Woo-
dc.contributor.authorLee, Jin Seok-
dc.contributor.authorChoi, Insung S.-
dc.contributor.authorKang, Kyungtae-
dc.contributor.authorYoon, Myung-Han-
dc.date.available2021-02-22T09:45:29Z-
dc.date.created2020-09-03-
dc.date.issued2018-05-
dc.identifier.issn1998-0124-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4528-
dc.description.abstractIn this study, we report that height-controlled vertically etched silicon nano-column arrays (vSNAs) induce strong growth cone-to-substrate coupling and accelerate In vitroneurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography-induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.-
dc.language영어-
dc.language.isoen-
dc.publisherTSINGHUA UNIV PRESS-
dc.titleStrong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Jin Seok-
dc.identifier.doi10.1007/s12274-017-1878-7-
dc.identifier.scopusid2-s2.0-85033405885-
dc.identifier.wosid000431999700019-
dc.identifier.bibliographicCitationNANO RESEARCH, v.11, no.5, pp.2532 - 2543-
dc.relation.isPartOfNANO RESEARCH-
dc.citation.titleNANO RESEARCH-
dc.citation.volume11-
dc.citation.number5-
dc.citation.startPage2532-
dc.citation.endPage2543-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.subject.keywordPlusMESENCHYMAL STEM-CELLS-
dc.subject.keywordPlusN-CADHERIN ADHESIONS-
dc.subject.keywordPlusNEURITE OUTGROWTH-
dc.subject.keywordPlusNANOWIRE ARRAYS-
dc.subject.keywordPlusHIPPOCAMPAL-NEURONS-
dc.subject.keywordPlusCYTOSKELETAL DYNAMICS-
dc.subject.keywordPlusSURFACE-PROPERTIES-
dc.subject.keywordPlusACTIN FLOW-
dc.subject.keywordPlusGUIDANCE-
dc.subject.keywordPlusTOPOGRAPHY-
dc.subject.keywordAuthorvertical silicon nanostructures-
dc.subject.keywordAuthormetal-assisted chemical etching-
dc.subject.keywordAuthorprimary hippocampal neurons-
dc.subject.keywordAuthorneurite outgrowth-
dc.subject.keywordAuthorcytoskeletal dynamics-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12274-017-1878-7-
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