MicroRNAs as critical regulators of the endothelial to mesenchymal transition in vascular biology
DC Field | Value | Language |
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dc.contributor.author | Kim, Jongmin | - |
dc.date.available | 2021-02-22T09:46:07Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4699 | - |
dc.description.abstract | The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. The EndMT process is tightly controlled by diverse signaling networks, similar to the epithelial to mesenchymal transition. Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. Thus, it is highly important to understand the molecular basis of miRNA control of EndMT. This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | MicroRNAs as critical regulators of the endothelial to mesenchymal transition in vascular biology | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2018.51.2.011 | - |
dc.identifier.scopusid | 2-s2.0-85042634194 | - |
dc.identifier.wosid | 000427612500004 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.51, no.2, pp 65 - 72 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 51 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 72 | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002318700 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | PULMONARY-HYPERTENSION | - |
dc.subject.keywordPlus | CARDIAC FIBROSIS | - |
dc.subject.keywordPlus | THERAPEUTIC IMPLICATIONS | - |
dc.subject.keywordPlus | MOLECULAR-BASIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | Endothelial cell | - |
dc.subject.keywordAuthor | Endothelial dysfunction | - |
dc.subject.keywordAuthor | Endothelial to mesenchymal transition | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | Vascular disease | - |
dc.identifier.url | http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2018.51.2.011 | - |
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