Human breast cancer cells display different sensitivities to ABT-263 based on the level of survivin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Gong, Eun-Yeung | - |
dc.contributor.author | Shin, Jae-Sik | - |
dc.contributor.author | Moon, Jai-Hee | - |
dc.contributor.author | Shim, Hyun Jae | - |
dc.contributor.author | Kim, Seung-Mi | - |
dc.contributor.author | Lee, Seul | - |
dc.contributor.author | Jeong, Joonyee | - |
dc.contributor.author | Gong, Ji Hee | - |
dc.contributor.author | Kim, Mi Jin | - |
dc.contributor.author | Lee, Dae Hee | - |
dc.contributor.author | Park, Yoon Sun | - |
dc.contributor.author | Shin, Jimin | - |
dc.contributor.author | Hong, Seung-Woo | - |
dc.contributor.author | Kim, Yeong Seok | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.date.available | 2021-02-22T09:46:08Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0887-2333 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4701 | - |
dc.description.abstract | ABT-263 (navitoclax), a Bcl-2 family protein inhibitor, was clinically tested as an anti-cancer agent. However, the clinical trials were limited given the occurrence of resistance to monotherapy in breast cancer cells. Our study investigates the mechanisms for overcoming navitoclax resistance by combining it with an mTOR inhibitor to indirectly target survivin. The apoptotic effects of navitoclax occurred in MDA-MB-231 breast cancer cells in a time-and dose-dependent fashion, but MCF-7 cells were resistant to navitoclax treatment. The expression of Bcl-2 family genes was not altered by navitoclax, but the expression of survivin, a member of the inhibitors of apoptosis proteins (IAP) family, was downregulated, which increased death signaling in MDA-MB-231 cells. In MCF-7 cells, a navitoclax-resistant cell line, combined treatment with navitoclax and everolimus synergistically reduced survivin expression and induced cell death. These data indicate that navitoclax induces cell death in MDA-MB-231 cells but not in MCF-7 cells. Decreased survivin expression in MDA-MB-231 cells may be a primary pathway for death signaling. Combined navitoclax and everolimus treatment induces cell death by reducing the stability of survivin in MCF-7 cells. Given that survivin-targeted therapy overcomes resistance to navitoclax, this strategy could be used to treat breast cancer patients. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Human breast cancer cells display different sensitivities to ABT-263 based on the level of survivin | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.tiv.2017.09.023 | - |
dc.identifier.scopusid | 2-s2.0-85031825882 | - |
dc.identifier.wosid | 000422811300027 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY IN VITRO, v.46, pp 229 - 236 | - |
dc.citation.title | TOXICOLOGY IN VITRO | - |
dc.citation.volume | 46 | - |
dc.citation.startPage | 229 | - |
dc.citation.endPage | 236 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | BCL-2 FAMILY PROTEINS | - |
dc.subject.keywordPlus | BCL-2/BCL-X-L/BCL-W INHIBITOR | - |
dc.subject.keywordPlus | LYMPHOMA-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EVEROLIMUS | - |
dc.subject.keywordPlus | ABT-737 | - |
dc.subject.keywordPlus | MTOR | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | Navitoclax (ABT-263) | - |
dc.subject.keywordAuthor | Everolimus | - |
dc.subject.keywordAuthor | Survivin | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0887233317302758?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.