Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soo-Yeon | - |
dc.contributor.author | Go, Ga-Yeon | - |
dc.contributor.author | Vuong, Tuan Anh | - |
dc.contributor.author | Kim, Jee Won | - |
dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Jo, Ayoung | - |
dc.contributor.author | An, Jun Min | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.contributor.author | Seo, Dong-Wan | - |
dc.contributor.author | Kim, Jin-Seok | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Kang, Jong-Sun | - |
dc.contributor.author | Lee, Sang-Jin | - |
dc.contributor.author | Bae, Gyu-Un | - |
dc.date.available | 2021-02-22T09:46:20Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.issn | 2093-4947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4761 | - |
dc.description.abstract | Background: Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods: BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting for myogenic regulators, immunostaining for a muscle marker, myosin heavy chain or immunoprecipitation analysis for myogenic transcription factors. Results: BG treatment of C2C12 cells resulted in the activation of Akt, thereby enhancing heterodimerization of MyoD and E proteins, which in turn promoted muscle-specific gene expression and myoblast differentiation. BG-treated myoblasts formed larger multinucleated myotubes with increased diameter and thickness, accompanied by enhanced Akt/mTOR/p70S6K activation. Furthermore, the BG treatment of human rhabdomyosarcoma cells restored myogenic differentiation. Conclusion: BG enhances myoblast differentiation and myotube hypertrophy by activating Akt/mTOR/p70S6k axis. Thus, our study demonstrates that BG has promising potential to treat or prevent muscle loss related to aging or other pathological conditions, such as diabetes. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.title | Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1016/j.jgr.2017.08.009 | - |
dc.identifier.scopusid | 2-s2.0-85030772812 | - |
dc.identifier.wosid | 000426606800016 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GINSENG RESEARCH, v.42, no.1, pp 116 - 121 | - |
dc.citation.title | JOURNAL OF GINSENG RESEARCH | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 121 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002407130 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | MUSCLE DIFFERENTIATION | - |
dc.subject.keywordPlus | GENE-TRANSCRIPTION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | MYOD | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Akt signaling | - |
dc.subject.keywordAuthor | black ginseng | - |
dc.subject.keywordAuthor | myoblast differentiation | - |
dc.subject.keywordAuthor | myogenic conversion | - |
dc.subject.keywordAuthor | myotube hypertrophy | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S122684531730235X?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.