IL-33-matured dendritic cells promote Th17 cell responses via IL-1 beta and IL-6
DC Field | Value | Language |
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dc.contributor.author | Park, Su-Ho | - |
dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Lim, Hui Xuan | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.available | 2021-02-22T10:46:42Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.issn | 1096-0023 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5085 | - |
dc.description.abstract | IL-33 is associated with a variety of autoimmune diseases, such as sclerosis, inflammatory bowel disease, and rheumatoid arthritis. Although IL-33 is mainly involved in the induction of Th2 cells, however, the relationship between IL-33 and Th17 cells is still largely unknown. In this study, we investigated the effects of IL-33 on DC-mediated CD4(+) T cell activation and Th17 cell differentiation because DCs are essential cells for presenting self-antigens to CD4(+) T cells in autoimmune disease conditions. OT-II mice were injected with IL-33-treated DCs or untreated DCs that were primed by OVA(323-339 )peptide, and their Thl 7 cell responses were compared. Th17 cell population and IL-17 expression levels were significantly increased in draining lymph nodes of mice injected with IL-33-treated DCs, compared with those in mice injected with untreated DCs. IL-33 treatment maturated DCs to present self-antigens and to increase production of proinflammatory cytokines such as IL-1 beta and IL-6, which have a crucial role in Th17 cell differentiation. We found that the IL-33-matured DCs enhanced the expression of an early T cell activation marker (CD69) and the Th17 master transcription factor (ROR gamma t), but IL-33 did not directly affect CD4(+) T cell differentiation or increase Th17 polarization. Notably, neutralizing IL-1 beta and/or IL-6 significantly decreased IL-17 expression levels and Th17 cell population which were increased by the coculture of CD4(+) T cells with IL-33-matured DCs, indicating that IL-33 may induce Th17 cell responses via IL-1 beta and IL-6 derived from IL-33-matured DCs. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.title | IL-33-matured dendritic cells promote Th17 cell responses via IL-1 beta and IL-6 | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.cyto.2017.07.022 | - |
dc.identifier.scopusid | 2-s2.0-85027871975 | - |
dc.identifier.wosid | 000416186500015 | - |
dc.identifier.bibliographicCitation | CYTOKINE, v.99, pp 106 - 113 | - |
dc.citation.title | CYTOKINE | - |
dc.citation.volume | 99 | - |
dc.citation.startPage | 106 | - |
dc.citation.endPage | 113 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | RECEPTOR ACCESSORY PROTEIN | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | LYMPHOID ORGANS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | AUTOIMMUNE | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordAuthor | Autoimmunity | - |
dc.subject.keywordAuthor | DC adoptive transfer | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordAuthor | T cell activation | - |
dc.subject.keywordAuthor | Th17 cell differentiation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S1043466617302223?via%3Dihub | - |
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