흰쥐에서 이부프로펜 리신염의 물리화학적 특성 및 약물동태에 관한 평가
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정연복 | - |
dc.contributor.author | 신대환 | - |
dc.contributor.author | 김태성 | - |
dc.contributor.author | 박승혁 | - |
dc.contributor.author | 김시현 | - |
dc.contributor.author | 조한준 | - |
dc.contributor.author | 한건 | - |
dc.date.accessioned | 2021-10-07T07:40:10Z | - |
dc.date.available | 2021-10-07T07:40:10Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/52623 | - |
dc.description.abstract | Two types of water soluble lysine salts of ibuprofen were prepared and evaluated. Physicochemical properties for ibuprofen-l-lysinate (IBL-l), ibuprofen-dl-lysinate (IBL-dl) and ibuprofen (IB) were studied on melting point, specific ratation, UV spectra and ^1H-NMR spectra. There were not differences between IBL-dl and IBL-l in UV spectra and 1H-NMR spectra. The pharmacokinetic parameters of IB were compared to those of its lysine salts (IBL-l and IBL-dl) after i.v. or oral administration at the dose of 50 mg/kg (calculated as IB). Total body clearance (CL_t) and area under the plasma concentration- time curve (AUC) were not different between IB group and IBL groups after i.v. administration. On the other hand, IBL-l and IBL-dl produced peak plasma concentrations (C_(max)) significantly ealier and higher than IB. Time to reach peak concentration (T_(max)) after IBL administration was lower than that after IB administration. There was no difference in AUC across all different groups (IB, IBL-l and IBL-dl) after oral administration. However, absorption rate constant (k_a) of IBL-l and IBL-dl were significantly increased than that of IB. These results indicated that the administration of IBL-l and IBL-dl may be advantageous if rapid and reliable onset of pain relief is required. | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한약학회 | - |
dc.title | 흰쥐에서 이부프로펜 리신염의 물리화학적 특성 및 약물동태에 관한 평가 | - |
dc.title.alternative | Physicochemical Characteristics and Pharmacokintics of Ibuprofen Lysine Salts | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.55, no.3, pp 260 - 266 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 260 | - |
dc.citation.endPage | 266 | - |
dc.identifier.kciid | ART001570754 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | ibuprofen | - |
dc.subject.keywordAuthor | lysinate | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | physicochemical properties | - |
dc.identifier.url | https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=JAKO201121055566663&SITE=CLICK | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.