Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation
DC Field | Value | Language |
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dc.contributor.author | 이혜림 | - |
dc.contributor.author | 박영숙 | - |
dc.contributor.author | 이아람 | - |
dc.contributor.author | 김현정 | - |
dc.contributor.author | 최지혜 | - |
dc.contributor.author | 피재호 | - |
dc.contributor.author | 박헌용 | - |
dc.contributor.author | 김종민 | - |
dc.date.available | 2021-02-22T10:49:55Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1225-9918 | - |
dc.identifier.issn | 2287-3406 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5397 | - |
dc.description.abstract | Homotypic cell adhesion (homotypic aggregation) in activated monocytes plays a central role in physiological and pathological processes including inflammatory responses, differentiation and migration. The extract of the Prunus mume Sieb. et Zucc. fruit (Maesil) has potential benefits to human health; such as anti-viral, anti-microbial, and anti-cancer activities. Indeed, Maesil extract may modulate inflammatory responses via interference with homotypic aggregation in monocytes. In the present study, the molecular mechanisms underpinning the therapeutic efficacy of Maesil extract in inflammatory diseases were investigated. It was found that Maesil extract inhibited homotypic aggregation in lipopolysaccharide (LPS)-activated monocytes. This was mediated by reduction of nitric oxide (NO) production, partly via inhibition of inducible nitric oxide synthase (iNOS) expression in LPS-activated THP-1 cells. It was confirmed that NO inhibition is a key mechanism in Maesil induced blockade of monocyte aggregation through identification of reversal of this inhibitory effect by the NO-producing agent S-nitroso-N-acetyl penicillamine (SNAP). In addition, Maesil extract significantly attenuated LPS-induced IκB-α phosphorylation and NF-κB translocation into the nucleus. In conclusion, Maesil extract exerts anti-inflammatory effects via inhibition of homotypic aggregation of LPS-activated monocytes through mechanisms involving the suppression of NO production and NF-κB activity, suggesting Maesil extract as a potential therapeutic candidate for the prevention and treatment of chronic inflammatory diseases. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국생명과학회 | - |
dc.title | Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation | - |
dc.title.alternative | 매실 추출물의 산화질소 생성과 NF-κB 활성 조절을 통한 LPS유도성 THP-1 세포 동형성 응집의 억제 효과 | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5352/JLS.2015.25.7.801 | - |
dc.identifier.bibliographicCitation | 생명과학회지, v.25, no.7, pp 801 - 809 | - |
dc.citation.title | 생명과학회지 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 801 | - |
dc.citation.endPage | 809 | - |
dc.identifier.kciid | ART002015251 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Homotypic aggregation | - |
dc.subject.keywordAuthor | inflammationnitric oxide | - |
dc.subject.keywordAuthor | maesil extract | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002015251 | - |
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