비호지킨림프종 환자의 발열성 호중구감소증에 대한 페그필그라스팀의 예방효과
DC Field | Value | Language |
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dc.contributor.author | 조주희 | - |
dc.contributor.author | 방준석 | - |
dc.date.available | 2021-02-22T10:50:04Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1226-6051 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5440 | - |
dc.description.abstract | Objective: Pegfilgrastim is recently introduced that is long acting G-CSF for prophylaxis of febrile neutropenia. Treatment of non- Hodgikin's lymphoma (NHL) with R-CHOP is classified with relative high risk of febrile neutropenia. The study evaluated the prophylactic effect of pegfilgrastim to reduce the incidence of febrile neutropenia associated with R-CHOP of patient in NHL. And the risk factors associated with the incidence of FN and related events were evaluated. Methods: This retrospective study reviews the Electronic Medical Record of 68 NHL patients who received R-CHOP chemotherapy in single center between September 2013 and August 2014. These patients were classified who receive prophylaxis pegfilgrastim or no prophylaxis. Results: Sixty eight patients received R-CHOP with NHL. In 144 cycles of patients receiving pegfilgrastim, compared with no prophylaxis 178 cycles, had a lower incidence of febrile neutropenia (5.5% vs. 23.6%, p = 0.001), grade 3 or grade 4 neutropenia (14.4% vs. 89.8%, p < 0.001) and neutropenia related events (p < 0.05). The risk of febrile neutropenia after prophylaxis was significantly associated with age ≥ 65 (OR: 5.87, 95% CI 1.07-32.27, p = 0.042), IPI ≥ 3 (OR: 7.2, 95% CI 1.31-39.6, p = 0.023), S.alb < 3.5 g/dL (OR: 31.01, 95% CI 6.32-152.17, p < 0.0001). In multiple logistic regression analysis, lower baseline serum albumin (OR: 21.1, 95% CI 3.8-116.98, p = 0.001) was significantly associated with occurrence of febrile neutropenia. Conclusion: The study recommends prophylactic pegfilgrastim through risk assessment of febrile neutropenia in patients with non-Hodgikin's lymphoma receiving R-CHOP. | - |
dc.format.extent | 14 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국임상약학회 | - |
dc.title | 비호지킨림프종 환자의 발열성 호중구감소증에 대한 페그필그라스팀의 예방효과 | - |
dc.title.alternative | Prophylactic Effect of Pegfilgrastim on Febrile Neutropenia in Patients with Non-Hodgikin’s Lymphoma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 한국임상약학회지, v.25, no.2, pp 80 - 93 | - |
dc.citation.title | 한국임상약학회지 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 93 | - |
dc.identifier.kciid | ART002006872 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | pegfilgrastim | - |
dc.subject.keywordAuthor | febrile neutropenia | - |
dc.subject.keywordAuthor | non-hodgikin's lymphoma | - |
dc.subject.keywordAuthor | R-CHOP regimen | - |
dc.subject.keywordAuthor | granulocyte colony stimulating factor | - |
dc.subject.keywordAuthor | risk factor | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002006872 | - |
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