Inhibition of melanin production and tyrosinase expression of ergosterol derivatives from Phellinus pini
DC Field | Value | Language |
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dc.contributor.author | Hong Y.J. | - |
dc.contributor.author | Jang A.R. | - |
dc.contributor.author | Yang K.S. | - |
dc.date.available | 2021-02-22T10:55:27Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1226-3907 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6297 | - |
dc.description.abstract | Three ergosterol derivatives, ergosta-4,6,8(14),22-tetraen-3-one (1), ergosta-7,24(28)-dien-3-ol (2), and 5,8-epidioxyergosta-6,22-dien-3-ol(3) were isolated from the fruit body of Phellinus pini. Their structures were based on spectroscopic methods including IR, MS, and NMR (1D and 2D). These compounds were evaluated for their activity to decrease melanin production in α-MSH (melanocyte stimulating hormone) activated B16F10 cells. Compound 1, 2, and 3 reduced melanin content in a dose-dependent manner at concentrations of 5~15 uM. They also suppressed the tyrosinase expression of protein and m-RNA level dose dependently by western blot analysis and RT-PCR experiment in B16F10 murine melanoma cells. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국생약학회 | - |
dc.title | Inhibition of melanin production and tyrosinase expression of ergosterol derivatives from Phellinus pini | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.scopusid | 2-s2.0-84887806870 | - |
dc.identifier.bibliographicCitation | Natural Product Sciences, v.19, no.3, pp 258 - 262 | - |
dc.citation.title | Natural Product Sciences | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 258 | - |
dc.citation.endPage | 262 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001804693 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | 5,8 epidioxyergosta 6,22 dien 3 ol | - |
dc.subject.keywordPlus | alpha intermedin | - |
dc.subject.keywordPlus | ergosta 4,6,8(14),22 tetraen 3 one | - |
dc.subject.keywordPlus | ergosta 7,24(28) dien 3 ol | - |
dc.subject.keywordPlus | ergosterol | - |
dc.subject.keywordPlus | melanin | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | monophenol monooxygenase | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | concentration (parameters) | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug activity | - |
dc.subject.keywordPlus | drug isolation | - |
dc.subject.keywordPlus | drug structure | - |
dc.subject.keywordPlus | enzyme activity | - |
dc.subject.keywordPlus | fungal cell | - |
dc.subject.keywordPlus | infrared spectrometry | - |
dc.subject.keywordPlus | mass spectrometry | - |
dc.subject.keywordPlus | melanogenesis | - |
dc.subject.keywordPlus | melanoma cell | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | nuclear magnetic resonance spectroscopy | - |
dc.subject.keywordPlus | Phellinus | - |
dc.subject.keywordPlus | Phellinus pini | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein synthesis inhibition | - |
dc.subject.keywordPlus | real time polymerase chain reaction | - |
dc.subject.keywordPlus | Western blotting | - |
dc.subject.keywordAuthor | B16F10 cells | - |
dc.subject.keywordAuthor | Ergosterol derivatives | - |
dc.subject.keywordAuthor | Melanin content | - |
dc.subject.keywordAuthor | Phellinus pini | - |
dc.subject.keywordAuthor | Tyrosinase | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=3177218 | - |
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