Taurine Enhances Anticancer Activity of Cisplatin in Human Cervical Cancer Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Taehee | - |
dc.contributor.author | Kim, An Keun | - |
dc.date.available | 2021-02-22T10:56:30Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.issn | 2214-8019 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6506 | - |
dc.description.abstract | Taurine is a nonessential amino acid and has a variety of physiological and pharmacological effects. Recently, protective effects of taurine against anticancer drugs on normal cells were investigated. But anticancer effects of taurine on cancer cells remain poorly understood. Therefore, we investigated the anticancer effects of taurine alone and combination of cisplatin with taurine in human cervical cancer cells. Single treatment of taurine decreased cell proliferation in a time-and dose-dependent manner. In co-treatment of cisplatin with taurine, cell proliferation was more decreased than single treatment of cisplatin. Reduced cell proliferation was caused by apoptosis induction. Thus, after treatment of cisplatin with taurine, apoptotic cells were investigated. Apoptotic cells were increased more than taurine or cisplatin alone. Induction of apoptosis was related to p53 expression and activation of caspase-3, caspase-6, caspase-7, and caspase-9. In present study, the results indicated that co-treatment of cisplatin with taurine was more effective than single treatment of cisplatin. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Taurine Enhances Anticancer Activity of Cisplatin in Human Cervical Cancer Cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/978-1-4614-6093-0_19 | - |
dc.identifier.scopusid | 2-s2.0-84878798534 | - |
dc.identifier.wosid | 000337057500019 | - |
dc.identifier.bibliographicCitation | Advances in Experimental Medicine and Biology, v.776, pp 189 - 198 | - |
dc.citation.title | Advances in Experimental Medicine and Biology | - |
dc.citation.volume | 776 | - |
dc.citation.startPage | 189 | - |
dc.citation.endPage | 198 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | DOXORUBICIN-INDUCED CARDIOTOXICITY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CARBOPLATIN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MICE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.