Synthesis, Cytotoxicity and Topoisomerase II Inhibitory Activity of Benzonaphthofurandionesopen accessSynthesis, Cytotoxicity and Topoisomerase II Inhibitory Activity of Benzonaphthofurandiones
- Other Titles
- Synthesis, Cytotoxicity and Topoisomerase II Inhibitory Activity of Benzonaphthofurandiones
- Authors
- Rhee, Hee-Kyung; Kwon, Youngjoo; Chung, Hwa-Jin; Lee, Sang Kook; ParkChoo, Hea-Young
- Issue Date
- Jul-2011
- Publisher
- 대한화학회
- Keywords
- Benzonaphthofurandiones; Cytotoxicity; Topoisomerase II
- Citation
- Bulletin of the Korean Chemical Society, v.32, no.7, pp 2391 - 2396
- Pages
- 6
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 32
- Number
- 7
- Start Page
- 2391
- End Page
- 2396
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6981
- DOI
- 10.5012/bkcs.2011.32.7.2391
- ISSN
- 0253-2964
1229-5949
- Abstract
- Benzonaphthofurandiones containing four coplanar fused aromatic rings were synthesized and evaluated for their cytotoxicity against five human cancer cell lines, and their inhibitory activity on topoisomerases. These benzonaphthofurandiones were prepared by condensation of 2,3-dichloronaphthoquinone and three aromatic diols with base catalysts in alcohol. The synthesized compounds were o-alkylated with six dialkylaminoalkyl halides. The hydroxy derivatives (8a-8g) exhibited relatively potent cytotoxicity among the prepared compounds. These compounds were evaluated as excellent inhibitors against topoisomerase II (topo II).
Especially, the hydroxy analogue with branched methyl side chain (8e) showed high cytotoxicity against cancer cell lines and good inhibitory activity on topo II.
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