Inhibitory effect of a sesquiterpene from artemisia iwayomogi on expression of inducible nitric oxide synthase by suppression of I-κBα degradation in LPS-stimulated RAW 264.7 cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Na Yeon | - |
dc.contributor.author | Koh, Hye Jin | - |
dc.contributor.author | Li, Hua | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T11:13:20Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1226-3907 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8306 | - |
dc.description.abstract | A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle from medicinal plants. A sesquiterpene identified as armefolin inhibited the production of nitric oxide (NO) and attenuated inducible nitric oxide synthase (iNOS) protein level in lipopoly-saccharide (LPS)-activated RAW 264.7 cells. Armefolin also down-regulated mRNA expressions of iNOS and pro-inflammatory cytokines, interleukin-1β and interleukin-6 in LPS-activated macrophages. Moreover, armefolin suppressed the degradation of inhibitory-κBα (I-κBα) in LPS-activated macrophages. These data suggest that armefolin from A. iwayomogi can suppress the LPS-induced production of NO and the expression of iNOS gene through inhibiting the degradation of I-κBα. Taken together, armefolin from A. iwayomogi might be a candidate as promising anti-inflammatory agent. © 2017, Korean Society of Pharmacognosy. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Pharmacognosy | - |
dc.title | Inhibitory effect of a sesquiterpene from artemisia iwayomogi on expression of inducible nitric oxide synthase by suppression of I-κBα degradation in LPS-stimulated RAW 264.7 cells | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.20307/nps.2017.23.2.92 | - |
dc.identifier.scopusid | 2-s2.0-85025154136 | - |
dc.identifier.bibliographicCitation | Natural Product Sciences, v.23, no.2, pp 92 - 96 | - |
dc.citation.title | Natural Product Sciences | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 92 | - |
dc.citation.endPage | 96 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002235536 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | I kappa B kinase alpha | - |
dc.subject.keywordPlus | inducible nitric oxide synthase | - |
dc.subject.keywordPlus | interleukin 1beta | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | lipopolysaccharide | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | sesquiterpene | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | Artemisia | - |
dc.subject.keywordPlus | Artemisia iwayomogi | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cell viability | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | drug mechanism | - |
dc.subject.keywordPlus | drug structure | - |
dc.subject.keywordPlus | gene expression regulation | - |
dc.subject.keywordPlus | IL 1beta gene | - |
dc.subject.keywordPlus | IL 6 gene | - |
dc.subject.keywordPlus | iNOS gene | - |
dc.subject.keywordPlus | macrophage activation | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | protein degradation | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | proton nuclear magnetic resonance | - |
dc.subject.keywordPlus | RAW 264.7 cell line | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | upregulation | - |
dc.subject.keywordAuthor | Armefolin | - |
dc.subject.keywordAuthor | Artemisia iwayomogi | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Sesquiterpene | - |
dc.identifier.url | https://synapse.koreamed.org/upload/SynapseData/PDFData/0228nps/nps-23-92.pdf | - |
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