Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines
DC Field | Value | Language |
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dc.contributor.author | Kim, K-E | - |
dc.contributor.author | Song, H. | - |
dc.contributor.author | Kim, T. S. | - |
dc.contributor.author | Yoon, D. | - |
dc.contributor.author | Kim, C-w | - |
dc.contributor.author | Bang, S. I. | - |
dc.contributor.author | Hur, D. Y. | - |
dc.contributor.author | Park, H. | - |
dc.contributor.author | Cho, D-H | - |
dc.date.available | 2021-02-22T11:14:22Z | - |
dc.date.issued | 2007-03 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.issn | 1476-5594 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8462 | - |
dc.description.abstract | Cell migration and angiogenesis are key steps in tumor metastasis. However, the mechanism of migration regulated by vascular endothelial growth factor ( VEGF), a potent regulator of angiogenesis, is not completely understood. This study examined the relationship between VEGF and migration, along with the mechanism involved in the VEGF-regulated migration of human gastric cancer cells. The level of cell migration was increased by recombinant human (rh) VEGF-165 in the VEGF receptor-2-expressing SNU-601 cells. Interleukin (IL)-18 is associated with the malignant progression of tumors. Accordingly, this study examined the effect of IL-18 on the migration of cancer cells in order to identify the factors involved in VEGF-enhanced migration. Inhibiting IL-18 markedly reduced the level of VEGF-enhanced migration, and IL-18 increased cell migration directly through filamentous-actin polymerization and tensin downregulation. It was confirmed that rhVEGF-165 increased IL-18 production significantly. An antioxidant and an extracellular signal-regulated kinase (ERK) 1/2-specific inhibitor blocked rhVEGF-165-enhanced IL-18 production. Accordingly, rhVEGF-165 increased the generation of region of interest (ROI) and activated the ERK1/2 pathway. These results suggest that rhVEGF-165 enhances IL-18 production via the generation of ROI and ERK1/2 phosphorylation, which results in the increased migration of gastric cancer cells. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/sj.onc.1209926 | - |
dc.identifier.scopusid | 2-s2.0-33847350645 | - |
dc.identifier.wosid | 000244558800011 | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.26, no.10, pp 1468 - 1476 | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 26 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1468 | - |
dc.citation.endPage | 1476 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | GAMMA-INDUCING FACTOR | - |
dc.subject.keywordPlus | IL-18 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | TENSIN | - |
dc.subject.keywordPlus | ACTS | - |
dc.subject.keywordAuthor | ERK1/2 | - |
dc.subject.keywordAuthor | F-actin | - |
dc.subject.keywordAuthor | IL-18 | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | tensin | - |
dc.subject.keywordAuthor | VEGF | - |
dc.identifier.url | https://www.nature.com/articles/1209926#Bib1 | - |
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