Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang-Jin | - |
dc.contributor.author | Leem, Young-Eun | - |
dc.contributor.author | Go, Ga-Yeon | - |
dc.contributor.author | Choi, Younhee | - |
dc.contributor.author | Song, Yoo Jin | - |
dc.contributor.author | Kim, Insol | - |
dc.contributor.author | Kim, Do Yoon | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Seo, Dong-Wan | - |
dc.contributor.author | Kang, Jong-Sun | - |
dc.contributor.author | Bae, Gyu-Un | - |
dc.date.available | 2021-02-22T11:15:22Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8588 | - |
dc.description.abstract | Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0175271 | - |
dc.identifier.scopusid | 2-s2.0-85017146187 | - |
dc.identifier.wosid | 000399371900144 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.12, no.4 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | (-)-EPICATECHIN | - |
dc.subject.keywordPlus | RESTRICTION | - |
dc.subject.keywordPlus | SARCOPENIA | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | TEA | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175271 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.