3',4',7,8-Tetrahydroxyflavone inhibits RANKL-induced osteoclast formation and bone resorption
DC Field | Value | Language |
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dc.contributor.author | Kang, J. H. | - |
dc.contributor.author | Jung, H. | - |
dc.contributor.author | Sy, Ji | - |
dc.contributor.author | Yim, M. | - |
dc.date.available | 2021-02-22T11:15:46Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0031-7144 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8628 | - |
dc.description.abstract | Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-tetrahydroxyflavone is a flavonoid from Acacia confusa. In the present study, we found that 3',4',7,8-tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7',8-tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K. In addition, 3',4',7',8-tetrahydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3',4',7',8-tetrahydroxyflavone inhibited RANKL-induced expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, ectopic overexpression of a constitutively active form of NFATc1 completely rescued the anti-osteoclastogenic effect of 3',4',7',8-tetrahydroxyflavone, suggesting that the anti-osteoclastogenic effect was mainly attributed to the reduction in NFATc1 expression. Taken together, our data suggest that 3',4',7',8-tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH | - |
dc.title | 3',4',7,8-Tetrahydroxyflavone inhibits RANKL-induced osteoclast formation and bone resorption | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1691/ph.2017.6845 | - |
dc.identifier.scopusid | 2-s2.0-85017307110 | - |
dc.identifier.wosid | 000396388200005 | - |
dc.identifier.bibliographicCitation | PHARMAZIE, v.72, no.3, pp 161 - 166 | - |
dc.citation.title | PHARMAZIE | - |
dc.citation.volume | 72 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 166 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CATHEPSIN-K | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PRECURSORS | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | NFAT | - |
dc.identifier.url | https://www.ingentaconnect.com/contentone/govi/pharmaz/2017/00000072/00000003/art00005 | - |
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