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Isoquinoline alkaloids from Coptis japonica stimulate the myoblast differentiation via p38 MAP-kinase and Akt signaling pathway
- Issue Date
- Mar-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Coptis japonica; Isoquinoline alkaloid; Myoblast differentiation; MyoD; p38 MAPK; Akt
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.6, pp 1401 - 1404
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 6
- Start Page
- 1401
- End Page
- 1404
- ISSN
- 0960-894X
1464-3405
- Abstract
- To overcome the muscle atrophy, such as cachexia and sarcopenia, we tried to find myogenic agents from medicinal plants. From myogenic extract of Coptis japonica, we purified six isoquinoline alkaloids and evaluated their effects on transactivation of myoD and MHC expression in C2C12 cells during differentiation process. Among obtained compounds, magnoflorine most efficiently enhanced the myoblast differentiation by activating the p38 MAP kinase and Akt pathway, and also increased the number of multinucleated and cylinder-shaped myotubes. These results propose that magnoflorine from Coptis japonica might be a promising lead compound for the development of anti-muscle atrophy drug. (C) 2017 Elsevier Ltd. All rights reserved.
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