DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case report
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyunah | - |
dc.contributor.author | Bang, Eun Sook | - |
dc.contributor.author | Lim, Seung-Kwan | - |
dc.contributor.author | Lee, Jae Myeong | - |
dc.date.available | 2021-02-22T11:24:07Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0946-1965 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9388 | - |
dc.description.abstract | Objective: To report a rare case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis (TB) drugs, which progressed to acute generalized exanthematous pustulosis (AGEP) after moxifloxacin treatment. Case summary: A 25-year-old female was hospitalized for dyspnea and dizziness. She had a history of TB and experienced rifampin-induced skin rash. She was treated for TB with moxifloxacin, isoniazid, ethambutol, and pyrazinamide. Upon admission, she had a fever of 39.2 degrees C, and aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and eosinophil count increased during the first 10 days after admission. The patient had a rash all over the body with itching, pain, and a burning sensation. Diagnosis of DRESS syndrome was made. Immunoglobulin and prednisolone administration improved the DRESS symptoms. After the first DRESS syndrome diagnosis, anti-TB medications were changed to isoniazid, ethambutol, pyrazinamide, cycloserine, and streptomycin, which also caused a skin rash, itching, and elevated AST/ALT levels, and eosinophil count. Then, the antiTB treatment was changed to cycloserine, streptomycin, ethionamide, and para-aminosalicylic acid. The rash and itching persisted and eosinophil count increased further. All TB medications were discontinued except streptomycin. Due to the flushing and a burning sensation by streptomycin at the injection site, it was replaced with moxifloxacin. The patient experienced erythematous pustules and patches on skin with desquamation, fissures, and swelling. Therefore, a diagnosis of moxifloxacin-induced AGEP was made. Conclusion: DRESS syndrome induced by anti-TB drugs developed in a 25-year-old woman with moxifloxacin-related subsequent AGEP. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DUSTRI-VERLAG DR KARL FEISTLE | - |
dc.title | DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case report | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.5414/CP202595 | - |
dc.identifier.scopusid | 2-s2.0-84990020608 | - |
dc.identifier.wosid | 000383275400009 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, v.54, no.10, pp 808 - 815 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | - |
dc.citation.volume | 54 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 808 | - |
dc.citation.endPage | 815 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SYSTEMIC SYMPTOMS DRESS | - |
dc.subject.keywordPlus | DRUG REACTION | - |
dc.subject.keywordPlus | HYPERSENSITIVITY-SYNDROME | - |
dc.subject.keywordPlus | EOSINOPHILIA | - |
dc.subject.keywordPlus | RASH | - |
dc.subject.keywordPlus | CARBAMAZEPINE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | AGEP | - |
dc.subject.keywordAuthor | drug hypersensitivity syndrome | - |
dc.subject.keywordAuthor | DRESS syndrome | - |
dc.subject.keywordAuthor | acute generalized exanthematous pustulosis | - |
dc.subject.keywordAuthor | anti-tuberculosis | - |
dc.subject.keywordAuthor | moxifloxacin | - |
dc.identifier.url | https://www.dustri.com/article_response_page.html?artId=14610&doi=10.5414/CP202595&L=0 | - |
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