Neuroprotective effect of mesenchymal stem cell through complement component 3 downregulation after transient focal cerebral ischemia in mice
DC Field | Value | Language |
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dc.contributor.author | Jung, Hye-Seon | - |
dc.contributor.author | Jeong, Si-Yeon | - |
dc.contributor.author | Yang, Jiwon | - |
dc.contributor.author | Kim, So-Dam | - |
dc.contributor.author | Zhang, Baojin | - |
dc.contributor.author | Yoo, Hyun Seung | - |
dc.contributor.author | Song, Sun U. | - |
dc.contributor.author | Jeon, Myung-Shin | - |
dc.contributor.author | Song, Yun Seon | - |
dc.date.available | 2021-02-22T11:24:17Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.issn | 1872-7972 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9400 | - |
dc.description.abstract | Bone marrow-derived mesenchymal stem cells (MSCs) are used in stroke treatment despite the poor understanding of its mode of action. The immune suppressive and anti-inflammatory properties of MSCs possibly play important roles in regulating neuroinflammation after stroke. We investigated whether MSCs reduce the inflammatory complement component 3 (C3) levels, thus, providing neuroprotection during stroke. Mice were subjected to transient focal cerebral ischemia (tFCI), after which MSCs were intravenously injected. The infarct volume of the brain was reduced in MSC-injected tFCI mice, and C3 expression was significantly reduced in both the brain and the blood. Additionally, the profiles of other inflammatory mediators demonstrated neuroprotective changes in the MSCs-treated group. In order to analyze the effect of MSCs on neurons during cerebral ischemia, primary cortical neurons were co cultured with MSCs under oxygen-glucose deprivation (OGD). Primary neurons co -cultured with MSCs exhibited reduced levels of C3 expression and increased protection against OGD, indicating that treatment with MSCs reduces excessive C3 expression and rescues ischemia-induced neuronal damage. Our finding suggests that reduction of C3 expression by MSCs can help to ameliorate ischemic brain damage, offering a new neuroprotective strategy in stroke therapy. (C) 2016 Published by Elsevier Ireland Ltd. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Neuroprotective effect of mesenchymal stem cell through complement component 3 downregulation after transient focal cerebral ischemia in mice | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.neulet.2016.09.032 | - |
dc.identifier.scopusid | 2-s2.0-84989210996 | - |
dc.identifier.wosid | 000386861500035 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, v.633, pp 227 - 234 | - |
dc.citation.title | NEUROSCIENCE LETTERS | - |
dc.citation.volume | 633 | - |
dc.citation.startPage | 227 | - |
dc.citation.endPage | 234 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | C3 | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordAuthor | Mesenchymal stem cell | - |
dc.subject.keywordAuthor | Complement component 3 | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | Cerebral ischemia | - |
dc.subject.keywordAuthor | Oxygen glucose deprivation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0304394016307157?via%3Dihub | - |
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