Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조대호 | - |
dc.contributor.author | 김정은 | - |
dc.contributor.author | 김종식 | - |
dc.contributor.author | 박현정 | - |
dc.date.available | 2021-02-22T11:24:44Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9457 | - |
dc.description.abstract | Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly understood, and the treatment of recalcitrant AD is still challenging. There is accumulating evidence for new gene polymorphisms related to the epidermal barrier function and innate and adaptive immunity in patients with AD. Newly-found T cells and dendritic cell subsets, cytokines, chemokines and signaling pathways have extended our understanding of the molecular pathomechanism underlying AD. Genetic changes caused by environmental factors have been shown to contribute to the pathogenesis of AD. We herein present a review of the genetics, epigenetics, barrier dysfunction and immunological abnormalities in AD with a focus on updated molecular biology. | - |
dc.format.extent | 30 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms17081234 | - |
dc.identifier.scopusid | 2-s2.0-84980357017 | - |
dc.identifier.wosid | 000382337900048 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.17, no.8, pp 1234 - 1263 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 17 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1234 | - |
dc.citation.endPage | 1263 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | THYMIC STROMAL LYMPHOPOIETIN | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | REGULATES FILAGGRIN EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | ANTIMICROBIAL SKIN BARRIER | - |
dc.subject.keywordPlus | COPY-NUMBER VARIATION | - |
dc.subject.keywordPlus | OF-FUNCTION VARIANTS | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | genetics | - |
dc.subject.keywordAuthor | epigenomics | - |
dc.subject.keywordAuthor | barrier | - |
dc.subject.keywordAuthor | immunologic abnormalities | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/17/8/1234 | - |
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