혈당상승억제 기능성 소재인 달맞이꽃종자 추출물의 지표물질 분석법의 통계적 검증에 대한 연구A Study on the Statistical Method for the Target Component of a Glucose-lowering Functional Material in Extracts of Evening Primerose Seeds
- Other Titles
- A Study on the Statistical Method for the Target Component of a Glucose-lowering Functional Material in Extracts of Evening Primerose Seeds
- Authors
- 박상욱; 이원재; 방준석
- Issue Date
- Mar-2016
- Publisher
- 한국임상약학회
- Keywords
- Evening primrose seeds; quality control; penta-o-galloyl β-D-glucose; uncertainty measurement
- Citation
- 한국임상약학회지, v.26, no.1, pp 70 - 76
- Pages
- 7
- Journal Title
- 한국임상약학회지
- Volume
- 26
- Number
- 1
- Start Page
- 70
- End Page
- 76
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9868
- ISSN
- 1226-6051
- Abstract
- Background: The use of the extracts from evening primrose seeds as a health functional food has been gradually increased.
Therefore, the monitoring and screening process has been considerably required for its quality control. Objective: This study aimed to estimate the measurement uncertainty associated with determination of penta-o-galloyl β-D-glucose (PGG) in extracts from evening primrose seeds by high-performance liquid chromatography. Methods: The sources of measurement uncertainty was expressed in accordance with mathematical/statistical theories of GUM & EURACHEM Guide. The expanded uncertainty was calculated by using the relative standard uncertainty between analytical result and sources of uncertainty in measurement (sample weight, final volume, extraction volume, standard solution, matrix and instrument etc). Results: In the results of 95% confidence interval, the uncertainty in measurement was 10,253.34 ± 1,844.50 μg/kg (k = 2.0). Conclusion: In this study, it showed that the value of uncertainty in measurement for determination of PGG in extracts from evening primrose seeds by HPLC has about 18.0% influence on PGG contents of the analytical results. The results would be very useful for the monitoring and screening of evening primrose seeds marketed in Korea for its quality control as dietary supplement.
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