Bakuchiol augments MyoD activation leading to enhanced myoblast differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang-Jin | - |
dc.contributor.author | Yoo, Miran | - |
dc.contributor.author | Go, Ga-Yeon | - |
dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Choi, Hyunmo | - |
dc.contributor.author | Leem, Young-Eun | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Seo, Dong-Wan | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Kang, Jong-Sun | - |
dc.contributor.author | Bae, Gyu-Un | - |
dc.date.available | 2021-02-22T11:28:07Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.issn | 1872-7786 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9907 | - |
dc.description.abstract | Myoblast differentiation is fundamental to skeletal muscle development and regeneration after injury and defects in this process are implicated in muscle atrophy associated with aging or pathological conditions. MyoD family transcription factors function as mater regulators in induction of muscle-specific genes during myoblast differentiation. We have identified bakuchiol, a prenylated phenolic monoterpene, as an inducer of MyoD-mediated transcription and myogenic differentiation. C2C12 myoblasts treated with bakuchiol exhibit enhanced muscle-specific gene expression and myotube formation. A key promyogenic kinase p38MAPK is activated dramatically by bakuchiol which in turn induced the formation of MyoD/E protein active transcription complexes. Consistently, the recruitment of MyoD and Baf60c to the Myogenin promoter is enhanced in bakuchiol-treated myoblasts. Furthermore, bakuchiol rescues defective p38MAPK activation and myogenic differentiation caused by Cdo-depletion or in RD rhabdomyosarcoma cells. Taken together, these results indicate that bakuchiol enhances myogenic differentiation through p38MAPK and MyoD activation. Thus bakuchiol can be developed into a potential agent to improve muscular regeneration and repair to treat muscular atrophy. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Bakuchiol augments MyoD activation leading to enhanced myoblast differentiation | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.cbi.2016.02.008 | - |
dc.identifier.scopusid | 2-s2.0-84958983115 | - |
dc.identifier.wosid | 000371398400007 | - |
dc.identifier.bibliographicCitation | CHEMICO-BIOLOGICAL INTERACTIONS, v.248, pp 60 - 67 | - |
dc.citation.title | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.volume | 248 | - |
dc.citation.startPage | 60 | - |
dc.citation.endPage | 67 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE DIFFERENTIATION | - |
dc.subject.keywordPlus | PSORALEA-CORYLIFOLIA | - |
dc.subject.keywordPlus | P38-ALPHA/BETA MAPK | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MYOGENESIS | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Bakuchiol | - |
dc.subject.keywordAuthor | Myoblast differentiation | - |
dc.subject.keywordAuthor | MyoD | - |
dc.subject.keywordAuthor | Myogenic conversion | - |
dc.subject.keywordAuthor | Muscle regeneration | - |
dc.subject.keywordAuthor | p38MAPK | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0009279716300448?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.