Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis
- Authors
- Kim, Jae Hyeon; Kim, Jin-Kyu; Ahn, Eun-Kyung; Ko, Hye-Jin; Cho, Young-Rak; Lee, Choong Hyun; Kim, Yong Kee; Bae, Gyu-Un; Oh, Joa Sub; Seo, Dong-Wan
- Issue Date
- Dec-2015
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Marmesin; Angiogenesis inhibitor; Vascular endothelial growth factor; VEGFR-2; beta 1 integrin
- Citation
- CANCER LETTERS, v.369, no.2, pp 323 - 330
- Pages
- 8
- Journal Title
- CANCER LETTERS
- Volume
- 369
- Number
- 2
- Start Page
- 323
- End Page
- 330
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10159
- DOI
- 10.1016/j.canlet.2015.09.021
- ISSN
- 0304-3835
1872-7980
- Abstract
- In the present study, we investigated the effects and molecular mechanism of marmesin, a coumarin compound isolated from Broussonetia kazinoki, on vascular endothelial growth factor-A (VEGF-A)-induced endothelial cell responses in vitro and angiogenic sprouting in aortic rings ex vivo. Marmesin treatment inhibited VEGF-A-stimulated endothelial cell proliferation through down-regulation of cell cycle-related proteins including cyclin-dependent kinases and cyclins, leading to pRb hypophosphorylation and G1 phase cell cycle arrest. In addition, marmesin treatment abrogated VEGF-A-induced endothelial cell migration, invasion and capillary-like structure formation in vitro as well as angiogenic sprouting ex vivo. These anti-angiogenic activities of marmesin were mediated through inactivation of VEGF-A-stimulated signaling pathways, and down-regulation of cell surface signaling molecules including VEGF receptor-2, human epidermal growth factor receptor-2, integrin beta 1 and integrin-liked kinase. Taken together, these findings clearly support the pharmacological roles of marmesin in regulating angiogenesis, and warrant further evaluation and development as a potential therapeutic agent for the treatment and prevention of angiogenesis-related diseases including cancer. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
-
Go to Link
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.