Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226
- Authors
- Gil, Minchan; Pak, Hyo-Kyung; Park, Seo-Jeong; Lee, A-Neum; Park, Young-Soo; Lee, Hyangsin; Lee, Hyunji; Kim, Kyung-Eun; Lee, Kyung Jin; Yoon, Dok Hyun; Chung, Yoo-Sam; Park, Chan-Sik
- Issue Date
- Oct-2015
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- CD99; BATF; AP-1; Proliferation; MAP kinase
- Citation
- IMMUNE NETWORK, v.15, no.5, pp 260 - 267
- Pages
- 8
- Journal Title
- IMMUNE NETWORK
- Volume
- 15
- Number
- 5
- Start Page
- 260
- End Page
- 267
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10218
- DOI
- 10.4110/in.2015.15.5.260
- ISSN
- 1598-2629
2092-6685
- Abstract
- CD99 signaling is crucial to a diverse range of biological functions including survival and proliferation. CD99 engagement is reported to augment activator protein-1 (AP-1) activity through mitogen-activated protein (MAP) kinase pathways in a T-lymphoblastic lymphoma cell line Jurkat and in breast cancer cell lines. In this study, we report that CD99 differentially regulated AP-1 activity in the human myeloma cell line RPMI8226. CD99 was highly expressed and the CD99 engagement led to activation of the MAP kinases, but suppressed AP-1 activity by inducing the expression of basic leucine zipper transcription factor, ATF-like (BATF), a negative regulator of AP-1 in RPMI8226 cells. By contrast, engagement of CD99 enhanced AP-1 activity and did not change the BATF expression in Jurkat cells. CD99 engagement reduced the proliferation of RPMI8226 cells and expression of cyclin 1 and 3. Overall, these results suggest novel CD99 functions in RPMI8226 cells.
- Files in This Item
-
Go to Link
- Appears in
Collections - 원격대학원 > 향장미용전공 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.