Abietic acid inhibits UVB-induced MMP-1 expression in human dermal fibroblast cells through PPAR alpha/gamma dual activation
- Authors
- Jeon, Youngsic; Jung, Yujung; Youm, Jong-Kyung; Kang, Ki Sung; Kim, Yong Kee; Kim, Su-Nam
- Issue Date
- Feb-2015
- Publisher
- WILEY
- Keywords
- abietic acid; AP-1; MMPs; NF-beta B; PPAR alpha/gamma; dual activator
- Citation
- EXPERIMENTAL DERMATOLOGY, v.24, no.2, pp 140 - 145
- Pages
- 6
- Journal Title
- EXPERIMENTAL DERMATOLOGY
- Volume
- 24
- Number
- 2
- Start Page
- 140
- End Page
- 145
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10680
- DOI
- 10.1111/exd.12616
- ISSN
- 0906-6705
1600-0625
- Abstract
- Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors and consist of three isotypes: PPAR, PPAR/ and PPAR. PPARs are expressed in various cell types in the skin, including keratinocytes, fibroblasts and infiltrating immune cells. Thus, these receptors are highly studied in dermato-endocrine research, and their ligands are targets for the treatment of various skin disorders, such as photoageing and chronological ageing of skin. Intensive studies have revealed that PPAR/ functions in photoageing and age-related inflammation by regulating matrix metalloproteinases (MMPs) via nuclear factor-kappa B (NF-B) and activator protein-1 (AP-1). However, the detailed mechanism of PPAR/'s role in photoageing has not yet been elucidated. In this study, we confirmed that abietic acid (AA) is a PPAR/ dual ligand and significantly decreased UVB-induced MMP-1 expression by downregulating UVB-induced MAPK signalling and downstream transcription factors, subsequently reducing IB degradation and blocking NF-B p65 nuclear translocation in Hs68 human dermal fibroblast cells. Treatment of cells with AA and GW6471 or bisphenol A diglycidyl ether (BADGE), PPAR or PPAR antagonists, respectively, reversed the effect on UVB-induced MMP-1 expression and inflammatory signalling pathway activation. Taken together, our data suggest that AA acts as a PPAR/ dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-B and the MAPK/AP-1 pathway and can be a useful agent for improving skin photoageing.
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