Multidrug and Toxic Compound Extrusion Protein-1 (MATE1/SLC47A1) Is a Novel Flavonoid Transporter
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji Hae | - |
dc.contributor.author | Lee, Jung Eun | - |
dc.contributor.author | Kim, Yeojin | - |
dc.contributor.author | Lee, Hojoung | - |
dc.contributor.author | Jun, Hee-jin | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.date.available | 2021-02-22T11:47:16Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.issn | 1520-5118 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10785 | - |
dc.description.abstract | Dietary flavonoids have various biological functions. However, thier cellular transport mechanisms are largely unknown. We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin. HEK293T cells overexpressing MATE1 exhibited increased intracellular quercetin accumulation. This effect disappeared in the presence of a MATE1 inhibitor and after MAE1 gene knockdown. HepG2 cells expressed MATE1 significantly, with the uptake quercetin of which was dramatically reduced with MATE1 inhibition. On the basis of immunofluorescence analysis MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum (ER) as well as in plasma membranes in the liver and intestine, which suggests potential accumulation of quercetin in peroxisomes and the ER in these tissues. Fluorescent microscopic analysis confirmed selective accumulation of qurcetin in peroxisome. The effects of quercetin on cellular lipid reduction and glucose uptake were exaggerated with MATE1 overexpression. In conclusion, MATE1 is a membrane transporter for quercetin; its overexpression enhances the hypolipidemic activity of quercetin and cellular. glucose transport Considering the low bioavialability of quercetin, appropriate regulation of MATE1 expression may optimize cellular quercetin concentrations and promote health benefits. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Multidrug and Toxic Compound Extrusion Protein-1 (MATE1/SLC47A1) Is a Novel Flavonoid Transporter | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1021/jf500916d | - |
dc.identifier.scopusid | 2-s2.0-84907919581 | - |
dc.identifier.wosid | 000343016200010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.40, pp 9690 - 9698 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 40 | - |
dc.citation.startPage | 9690 | - |
dc.citation.endPage | 9698 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | CATION ANTIPORTERS | - |
dc.subject.keywordPlus | HEPG2 CELLS | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | MATE1 | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | BILITRANSLOCASE | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordAuthor | flavonoid transporter | - |
dc.subject.keywordAuthor | multidrug and toxic compound extrusion transporter 1 | - |
dc.subject.keywordAuthor | lipid metabolism | - |
dc.subject.keywordAuthor | quercetin | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/jf500916d | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.