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Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors

Authors
Lee, Young BokKim, Hee JungJung, Hwa YoungPark, Yong GyuKim, Si YongCho, Baik KeeCho, DaehoPark, Hyun Jeong
Issue Date
Jun-2014
Publisher
WILEY-BLACKWELL
Citation
INTERNATIONAL JOURNAL OF DERMATOLOGY, v.53, no.6, pp 723 - 730
Pages
8
Journal Title
INTERNATIONAL JOURNAL OF DERMATOLOGY
Volume
53
Number
6
Start Page
723
End Page
730
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10879
DOI
10.1111/ijd.12057
ISSN
0011-9059
1365-4632
Abstract
BackgroundErythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors. MethodsTo investigate the expression of erythroid differentiation regulator 1 in normal skin and various skin tumors, immunohistochemical analysis of normal skin, epidermal tumors, sebaceous tumors, and eccrine tumors was performed. The image analysis was quantitatively performed using HistoQuant software. ResultsErythroid differentiation regulator 1 was strongly expressed in the nuclei of normal epidermis, sebaceous gland, eccrine gland, vessel, and nerve. Expression of erythroid differentiation regulator 1 was weak in seborrheic keratosis, sebaceous hyperplasia, and eccrine spiradenoma. Erythroid differentiation regulator 1 was rarely observed in malignant skin tumors, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sebaceous carcinoma, and eccrine porocarcinoma. ConclusionsThe expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. The results support the role of erythroid differentiation regulator 1 in cutaneous carcinogenesis and indicate its potential as a novel marker of skin tumors.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles

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