Emerging Roles of Orphan Nuclear Receptors in Cancer
- Authors
- Baek, Sung Hee; Kim, Keun Il
- Issue Date
- Feb-2014
- Publisher
- ANNUAL REVIEWS
- Keywords
- ERRs; RORs; Nur77; LRH-1; p53; beta-catenin
- Citation
- ANNUAL REVIEW OF PHYSIOLOGY, v.76, pp 177 - 195
- Pages
- 19
- Journal Title
- ANNUAL REVIEW OF PHYSIOLOGY
- Volume
- 76
- Start Page
- 177
- End Page
- 195
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11135
- DOI
- 10.1146/annurev-physiol-030212-183758
- ISSN
- 0066-4278
1545-1585
- Abstract
- A growing body of evidence suggests that a subset of orphan nuclear receptors are amplified and prognostic for some human cancers. However, the specific roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood. In this review, we summarize recent progress in elucidating the direct and indirect involvement of orphan nuclear receptors in cancer as well as their therapeutic potential in a variety of human cancers. Furthermore, we contrast the role of orphan nuclear receptors in cancer with the known roles of estrogen receptor and androgen receptor in hormone-dependent cancers.
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