생쥐에서 C1q/TNF-α Related Protein 1의 발세포 특이적 발현Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice
- Other Titles
- Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice
- Authors
- 조근자; 양영; 이영호; 김수일
- Issue Date
- Dec-2013
- Publisher
- 대한체질인류학회
- Keywords
- 발세포; CTRP1; 토리굳음증; 단백뇨; 토리 여과; Podocyte; CTRP1; Glomerulosclerosis; Proteinuria; Glomerular filtration
- Citation
- 해부·생물인류학, v.26, no.4, pp 147 - 153
- Pages
- 7
- Journal Title
- 해부·생물인류학
- Volume
- 26
- Number
- 4
- Start Page
- 147
- End Page
- 153
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11454
- ISSN
- 2671-5651
2671-566X
- Abstract
- C1q/TNF-α Related Protein 1 (CTRP1), an adiponectin paralog, is a novel member of the C1q-TNF Related Protein family. CTRP1 is expressed in the kidney, although its localization and role in the kidney have not been studied. This study examined CTRP1 expression and function in the kidney.
CTRP1 immunohistochemistry and PAS staining of the kidneys of C57/BL6 and FGS/Nga mice were performed.
In situ hybridization for podocin in the kidney was also performed.
CTRP1 immunoreactivity was found only in the glomeruli of the kidney. The CTRP1-immunoreactive cells in the glomeruli were identified as podocytes. The number of CTPR1-immunoreactive cells and the intensity of CTRP1 immunoreactivity were lower in the glomeruli of FGS/Nga mice, which develop progressive proteinuria and focal glomerulosclerosis.
CTRP1 is a novel protein expressed in podocytes of the mouse kidney and may have a role in podocytes related to glomerular filtration in the kidney.
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