동일날짜 처방전 2매 이상인 외래 소아환자 의약품처방의 적정성에 대한 후향적 평가

Abstract

This study was to describe inappropriate drug use in outpatient pediatrics who having 2 or more same-day prescriptions. Retrospective drug utilization reviews(DURs) were implemented to samples from national health insurance claims data during December 2008 to February 2009 nationwide, using 5 DUR criteria(duplication, drug-drug interaction, drugdisease interaction, drug-age contraindication, incorrect dosage) established in the Drug Information Framework(DIF)-Korea™ DUR program. Among 38,451 claims analyzed in the study, 74.7% had one or more conflicts in the 5 DUR modules. Among 16,472 patients analyzed, 49.6% had conflicts with duplication criteria composing ingredient duplication(23.3%) and therapeutic class duplication(39.6%). Incorrect dosages were found in 73.6% of patients and under-dosage conflict accounted for 59.9% which is higher than over-dosage conflict(38.3%). In this study, inappropriate drug prescriptions such as under-dose, pediatric contraindication and therapeutic duplication were prevalent in pediatrics outpatient setting, suggesting much more awareness in a societal perspective, to prevent drug related problems in a vulnerable pediatric group.