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Inhibition of nitric oxide production, iNOS and COX-2 expression of ergosterol derivatives from Phellinus pini
- Authors
- Hong Y.J.; Reum Jang A.; Jang H.J.; Yang K.S.
- Issue Date
- Sep-2012
- Publisher
- 한국생약학회
- Keywords
- COX-2; iNOS; Nitric Oxide; Phellinus pini; RAW 264.7 cells
- Citation
- Natural Product Sciences, v.18, no.3, pp 147 - 152
- Pages
- 6
- Journal Title
- Natural Product Sciences
- Volume
- 18
- Number
- 3
- Start Page
- 147
- End Page
- 152
- ISSN
- 1226-3907
- Abstract
- Ergosta-4,6,8(14),22-tetraen-3-one (1), ergosta-7,24(28)-dien-3-ol (2), and 5,8-epidioxyergosta-6,22- dien-3-ol(3) were isolated from the fruit body of Phellinus pini. Their structures were based on spectroscopic methods including IR, MS, and NMR (1D and 2D). These compounds were screened for their ability to inhibit nitric oxide (NO) production in LPS-activated RAW 264.7 cells. Compounds 1, 2, and 3 reduced NO production in the assay with IC50 values of 29.7 μM (1), 15.1 μM (2), and 18.4 μM (3) respectively. They also suppressed the expression of protein and m-RNA of iNOS and COX-2 in a dose dependent manner by western blot analysis and RT-PCR experiment in LPS-activated microglial cells.
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