Detailed Information
Cited 0 time in 
Cited 33 time in 
Cited 33 time in
Metadata Downloads
Atomic-level investigations on the amyloid-beta dimerization process and its driving forces in water
- Authors
- Chong, Song-Ho; Ham, Sihyun
- Issue Date
- Dec-2012
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- PHYSICAL CHEMISTRY CHEMICAL PHYSICS, v.14, no.5, pp 1573 - 1575
- Pages
- 3
- Journal Title
- PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Volume
- 14
- Number
- 5
- Start Page
- 1573
- End Page
- 1575
- ISSN
- 1463-9076
1463-9084
- Abstract
- We report the spontaneous dimerization process of the full-length A beta 42 proteins in water by using unguided, fully atomistic, explicit-water molecular dynamics simulations. Based on the thermodynamic analysis, we demonstrate that A beta 42 dimerization in water occurs via a two-step nucleation-accommodation mechanism driven by water-induced force and by protein internal force, respectively.
- Files in This Item
- Go to Link
- Appears in
Collections - 이과대학 > 화학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.