Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells
- Authors
- Park, Ga Bin; Kim, Yeong Seok; Lee, Hyun-Kyung; Song, Hyunkeun; Kim, Seonghan; Cho, Dae-Ho; Hur, Dae Young
- Issue Date
- 27-Dec-2011
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- EBV; B cell; Salubrinal; ROS; p38 MAPK; Bax; Calcium; Apoptosis
- Citation
- CANCER LETTERS, v.313, no.2, pp 235 - 248
- Pages
- 14
- Journal Title
- CANCER LETTERS
- Volume
- 313
- Number
- 2
- Start Page
- 235
- End Page
- 248
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12415
- DOI
- 10.1016/j.canlet.2011.09.011
- ISSN
- 0304-3835
1872-7980
- Abstract
- Salubrinal is a specific eIF2 alpha phosphatase inhibitor that inhibits ER stress-mediated apoptosis. However, maintaining hyper-phosphorylated eIF2 alpha state with high doses of salubrinal treatment promotes apoptosis in some cancer cells. In this report, we found that salubrinal induced apoptosis of EBV-transformed B cells. Notably, salubrinal induced ROS generation and p38 MPAK activation, which then induced expression of FasL. Moreover, salubrinal subsequently led to activation of caspases, calcium redistribution, Bax translocation, cytochrome c release, and apoptosis. These findings suggest that salubrinal may be a novel therapeutic approach for EBV-associated malignant diseases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.