Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.open access
- Authors
- Spannhoff, A.; 김용기; Raynal, N.J.-M.; Gharibyan, V.; Su, Ming-Bo; Zhou, Yue-Yang; Li, Jia; Castellano, Sabrina; Sbardella, Gianluca; Issa, Jean-Pierre J.; Bedford, Mark T.
- Issue Date
- Mar-2011
- Publisher
- Nature Publishing Group
- Citation
- EMBO Reports, v.12, no. 3, pp 238 - 243
- Pages
- 6
- Journal Title
- EMBO Reports
- Volume
- 12
- Number
- 3
- Start Page
- 238
- End Page
- 243
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12632
- DOI
- 10.1038/embor.2011.9
- ISSN
- 1469-221X
1469-3178
- Abstract
- Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly-the secretion produced by the hypopharyngeal and mandibular glands of worker bees-has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly. © 2011 European Molecular Biology Organization Embo.
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