Anti-inflammatory, anti-angiogenic, and anti-nociceptive activities of the chloroform fraction of a methanol extract from Rosa davurica Pall. leaves in experimental animal models
DC Field | Value | Language |
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dc.contributor.author | Jung, Hyun-Joo | - |
dc.contributor.author | Sa, Jae-Hoon | - |
dc.contributor.author | Song, Yun Seon | - |
dc.contributor.author | Shim, Tae-Heum | - |
dc.contributor.author | Park, Eun-Hee | - |
dc.contributor.author | Lim, Chang-Jin | - |
dc.date.available | 2021-02-22T13:18:11Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.issn | 1532-2513 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12641 | - |
dc.description.abstract | Rosa davurica Pall. has been traditionally used to treat inflammatory diseases and tumors. Its dried leaves were extracted with absolute methanol, and the methanol extract was successively fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions. Anti-angiogenic and anti-nociceptive activities were determined using the chick embryo chorioallantoic membrane (CAM) assay and acetic acid-induced writhing response, respectively. Anti-inflammatory activity was evaluated using two in vivo mouse models, acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air-pouch. The methanol extract gave rise to significant inhibition in the CAM angiogenesis, and showed marked 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Among the fractions prepared from the methanol extract, the chloroform fraction exhibited highest inhibitory effect in the CAM angiogenesis. The chloroform fraction displayed anti-inflammatory activities in vascular permeability and air-pouch models. In the air-pouch model, it was able to diminish exudate volume, number of polymorphonulcear leukocytes, and nitrite content. It also showed anti-nociceptive activity in the writhing response model in mice. The leaves of R. davurica possess anti-angiogenic and related anti-inflammatory and anti-nociceptive activities, which would provide some therapeutic support on its traditional use.</. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Anti-inflammatory, anti-angiogenic, and anti-nociceptive activities of the chloroform fraction of a methanol extract from Rosa davurica Pall. leaves in experimental animal models | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3109/08923973.2010.491516 | - |
dc.identifier.scopusid | 2-s2.0-79551578435 | - |
dc.identifier.wosid | 000287087800026 | - |
dc.identifier.bibliographicCitation | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, v.33, no.1, pp 186 - 192 | - |
dc.citation.title | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 186 | - |
dc.citation.endPage | 192 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | INHIBITS ANGIOGENESIS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordAuthor | air-pouch model | - |
dc.subject.keywordAuthor | anti-angiogenic | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | anti-nociceptive | - |
dc.subject.keywordAuthor | chorioallantoic membrane | - |
dc.subject.keywordAuthor | Rosa davurica Pall. | - |
dc.subject.keywordAuthor | vascular permeability | - |
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