Anti-inflammatory, anti-angiogenic, and anti-nociceptive activities of the chloroform fraction of a methanol extract from Rosa davurica Pall. leaves in experimental animal models
- Authors
- Jung, Hyun-Joo; Sa, Jae-Hoon; Song, Yun Seon; Shim, Tae-Heum; Park, Eun-Hee; Lim, Chang-Jin
- Issue Date
- Mar-2011
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- air-pouch model; anti-angiogenic; anti-inflammatory; anti-nociceptive; chorioallantoic membrane; Rosa davurica Pall.; vascular permeability
- Citation
- IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, v.33, no.1, pp 186 - 192
- Pages
- 7
- Journal Title
- IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Volume
- 33
- Number
- 1
- Start Page
- 186
- End Page
- 192
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12641
- DOI
- 10.3109/08923973.2010.491516
- ISSN
- 0892-3973
1532-2513
- Abstract
- Rosa davurica Pall. has been traditionally used to treat inflammatory diseases and tumors. Its dried leaves were extracted with absolute methanol, and the methanol extract was successively fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions. Anti-angiogenic and anti-nociceptive activities were determined using the chick embryo chorioallantoic membrane (CAM) assay and acetic acid-induced writhing response, respectively. Anti-inflammatory activity was evaluated using two in vivo mouse models, acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air-pouch. The methanol extract gave rise to significant inhibition in the CAM angiogenesis, and showed marked 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Among the fractions prepared from the methanol extract, the chloroform fraction exhibited highest inhibitory effect in the CAM angiogenesis. The chloroform fraction displayed anti-inflammatory activities in vascular permeability and air-pouch models. In the air-pouch model, it was able to diminish exudate volume, number of polymorphonulcear leukocytes, and nitrite content. It also showed anti-nociceptive activity in the writhing response model in mice. The leaves of R. davurica possess anti-angiogenic and related anti-inflammatory and anti-nociceptive activities, which would provide some therapeutic support on its traditional use.</.
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