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Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association StudyLack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
- Other Titles
- Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
- Issue Date
- Jun-2011
- Publisher
- 한국유전체학회
- Keywords
- genome-wide association study (GWAS); body mass index (BMI); Korean; single nucleotide polymorphism (SNP)
- Citation
- Genomics & Informatics, v.9, no.2, pp 59 - 63
- Pages
- 5
- Journal Title
- Genomics & Informatics
- Volume
- 9
- Number
- 2
- Start Page
- 59
- End Page
- 63
- ISSN
- 1598-866X
2234-0742
- Abstract
- Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40∼60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12,NFE2L3, MC4R and FTO) having p＜1×10^(-5). However,in the replication study, only melanocortin 4 receptor gene (MC4R ) (rs9946888, p=4.58×10^(-7)) was replicated with marginal significance (p＜0.05) in the second cohort (n=5,102, age 40∼60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
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