Detailed Information

Cited 0 time in webofscience Cited 46 time in scopus
Metadata Downloads

Platycodin D Induces Apoptosis in MCF-7 Human Breast Cancer Cells

Authors
Yu, Ji SunKim, An Keun
Issue Date
Apr-2010
Publisher
MARY ANN LIEBERT, INC
Keywords
apoptosis; breast cancer; death receptor pathway; mitochondrial pathway; mitogen-activated protein kinase; platycodin D; reactive oxygen species
Citation
JOURNAL OF MEDICINAL FOOD, v.13, no.2, pp.298 - 305
Journal Title
JOURNAL OF MEDICINAL FOOD
Volume
13
Number
2
Start Page
298
End Page
305
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13228
DOI
10.1089/jmf.2009.1226
ISSN
1096-620X
Abstract
Platycodin D (PD), a major constituent isolated from the root of Platycodon grandiflorum, has been suggested to possess anticancer activities, as indicated by its capabilities to induce mitotic arrest and apoptosis in several cancer cells. However, little is known of the underlying action mechanism. This study is the first to investigate the anticancer effect of PD in the human breast cancer cell, MCF-7. Our data showed that PD exhibited marked cell growth inhibition by inducing apoptosis. This induction was associated with activation of caspase-8 and -9 activities and poly(ADP-ribose) polymerase. PD triggered the mitochondrial apoptotic pathway, as indicated by up-regulation of levels of cellular Bax and down-regulation of levels of Bcl-2 and caspase-9 activation. We found that PD induced proteolytic activation of Bid, a member of the proapoptotic Bcl-2 family, implicating PD-induced apoptosis as possibly being functionally linked to a death receptor-mediated pathway. The PD treatment also was accompanied by an increase in cellular generation of reactive oxygen species, indicating that PD-induced apoptosis is likely to be mediated through mitochondrial dysfunction. In addition, we revealed that the mitogen-activated protein kinases, including extracellular signal-regulated kinase 1/2, c-Jun NH2-terminal kinase 1/2, and p38, which play important roles in apoptosis, were activated by treatment with PD. These results provide a basic mechanism for the anticancer properties of PD and suggest that PD is a promising candidate for chemotherapy and chemoprevention of breast cancer.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE