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호장으로부터 분리한 안트라퀴논류의 Nitric Oxide 저해활성Inhibition of Nitric Oxide Production by Anthraquinones from Polygonum cuspidatum
- Other Titles
- Inhibition of Nitric Oxide Production by Anthraquinones from Polygonum cuspidatum
- Issue Date
- Oct-2010
- Publisher
- 대한약학회
- Keywords
- Polygonum cuspidatum; emodin; emodin 8-O-β-D-glucopyranoside; emodin 1-O-β-D-glucopyranoside; antiinflammatory agents
- Citation
- 약 학 회 지, v.54, no.5, pp 387 - 391
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 54
- Number
- 5
- Start Page
- 387
- End Page
- 391
- ISSN
- 0377-9556
- Abstract
- Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea and inflammation in traditional medicine. We examined anti-inflammatory activities by the inhibition of NO production in RAW264.7 murine macrophages cells. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin (1), emodin 8-O-β-D-glucopyranoside (2), emodin 1-O-β-D-glucopyranoside (3). Antioxidative activities of these compounds were determined by measuring the radical scavenging effects on DPPH radicals. Compounds 1 and 3 showed potent activities compared with L-NMMA. These results suggested that the antraquinone compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.
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