홍삼섭취가 뇨 중 Bisphenol A 및 MDA 농도에 미치는 영향

Abstract

Bisphenol A [2,2-bis(4-hydroxyphenyl)propane, BPA], an endocrine disrupting chemical, is suspected to have reproductive toxicity or acceleration of carcinogenesis via oxidative metabolites, e.g. reactive quinone or semiquinone. Particularly, fertile women are high susceptible for BPA-induced toxicity for thyroid cancer or pregnancy. Thus, it is important to discover chemopreventive agent against BPA. The Korean Red Jinseng (KRG) exhibited various biological effects including detoxification of xenobiotics and antioxidant activities. In the present study, we performed pharmacokinetic analyses and studied the changes in oxidative stress, e.g. levels of malondialdehyde (MDA), due to KRG intake to clarify chemopreventive effects of KRG against BPA among Korean fertile women. Urine samples were collected from healthy fertile women (N=13; age, 23.50±1.79 yrs). We used reverse phase-HPLC/FLD for analyses of urinary BPA. Limit of detection(LOD) of BPA was 0.2 ng/ml. As results, median of urinary BPA was 2.27 ug/g creatinine. There was weak decrease of urinary BPA with KRG intake (β=－0.04, p=0.57). In addition, positive association between urinary BPA and MDA levels in this study(β=0.16, and p=0.08)confirmed BPA-induced oxidative stress. Moreover, KRG intake somewhat reduced the levels of MDA (β=－0.06, p=0.12). Thus, our pilot study suggests that KRG is chemopreventive to BPA via antioxidative mechanisms. Pharmacokinetic effects of KRG on BPA, e.g. absorption, metabolism, and excretion of BPA,should be further studied.