Detailed Information

Cited 0 time in webofscience Cited 38 time in scopus
Metadata Downloads

Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals

Authors
Jung, Hyun-JooPark, Eun-HeeLim, Chang-Jin
Issue Date
Oct-2009
Publisher
WILEY
Keywords
anti-angiogenic; anti-inflammatory; antinociceptive; coenzyme Q(10); mitochondria
Citation
JOURNAL OF PHARMACY AND PHARMACOLOGY, v.61, no.10, pp.1391 - 1395
Journal Title
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume
61
Number
10
Start Page
1391
End Page
1395
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13680
DOI
10.1211/jpp/61.10.0017
ISSN
0022-3573
Abstract
Objectives This work aimed to assess some pharmacological activities of coenzyme Q(10) (CoQ(10)) in animal experimental models. Methods The chick chorioallantoic membrane assay was used to evaluate anti-angiogenic activity of CoQ(10). Anti-inflammatory activity of CoQ(10) was confirmed using two animal models of inflammation. These were the vascular permeability and air pouch models, models of acute and sub-acute inflammation, respectively. Antinociceptive activity was assessed by the acetic acid-induced abdominal constriction response. Key findings CoQ(10) dose-dependently displayed inhibition of chick chorioallantoic membrane angiogenesis. In the acetic acid-induced vascular permeability model in mice, CoQ(10) at 50, 100 and 200 mg/kg reduced vascular permeability from 0.74 +/- 0.01 (A(590)) to 0.67 +/- 0.01 (P < 0.01), 0.46 +/- 0.02 (P < 0.01) and 0.30 +/- 0.01 (P < 0.01), respectively. In the carrageenan-induced inflammation in the air pouch, CoQ(10) was able to diminish exudate volume, the number of polymorphonulcear leucocytes and nitrite content in the air pouches. CoQ(10) at 25, 50 and 100 mg/kg significantly reduced acetic acid-induced abdominal constriction in mice from 27.0 +/- 2.00 (number of abdominal constrictions) to 17.7 +/- 0.33 (P < 0.01), 9.3 +/- 0.67 (P < 0.01) and 1.3 +/- 0.33 (P < 0.01), respectively, suggesting a strong antinociceptive activity. Conclusions CoQ(10) possessed considerable anti-angiogenic, anti-inflammatory and antinociceptive activity, possibly via down-regulating the level of nitric oxide, which partly supported its use as a dietary supplement and in combination therapy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE