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Expression of ADAM33 Is a Novel Regulatory Mechanism in IL-18-Secreted Process in Gastric Cancer

Authors
Kim, Kyung-EunSong, HyunkeunHahm, CandaceYoon, Sun YoungPark, SunyoungLee, Ha-reumHur, Dae YoungKim, TaesungKim, Cherl-hyunBang, Sa IkBang, Jung-WookPark, HyunjeongCho, Dae-Ho
Issue Date
Mar-2009
Publisher
AMER ASSOC IMMUNOLOGISTS
Citation
JOURNAL OF IMMUNOLOGY, v.182, no.6, pp.3548 - 3555
Journal Title
JOURNAL OF IMMUNOLOGY
Volume
182
Number
6
Start Page
3548
End Page
3555
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13803
DOI
10.4049/jimmunol.0801695
ISSN
0022-1767
Abstract
IL-18 has recently been reported to play a critical role in tumor migration, invasion, and metastasis. Because IL-18 has various biological activities after its secretion as an 18 kDa mature form, the regulation of the IL-18 secretion process is an important step in tumor progression. This study investigated the implication of IL-18 in vascular endothelial growth factor (VEGF)-D-regulated migration, along with the role of the IL-18 secretion process. VEGF-D enhanced cell migration, which was then blocked by inhibiting IL-18. VEGF-D increased 11,48 expression and secretion, suggesting that IL-18 is a critical mediator for VEGF-D-enhanced migration. VEGF-D induced a disintegrin and metalloprotease 33 (ADAM33) expression, which has a metalloproteinase domain. VEGF-D-enhanced IL-18 secretion and cell migration were inhibited by ADAM33 knock-down. Moreover, cell proliferation was considerably reduced in ADAM33 small interfering RNA transfectants. In conclusion, ADAM33 has a key role in gastric cancer pathogenesis by up-regulating IL-18 secretion process, resulting in increased cell migration and proliferation. The Journal of Immunology, 2009, 182: 3548-3555.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
원격대학원 > 향장미용학과 > 1. Journal Articles

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Kim, Kyung Eun
원격대학원 (향장미용학과)
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