Detailed Information
Cited 0 time in 
Cited 1 time in 
Cited 1 time in
Metadata Downloads
Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562
- Authors
- Park, Sunyoung; Kim, Tae Sung; Kim, Cherlhyun; Kim, Seonghan; Bang, Sa Ik; Park, Hyunjeong; Cho, Dae-Ho
- Issue Date
- Feb-2009
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Transferrin; Apo-transferrin; Interleukin-18 (IL-18); Proliferation; Leukemia
- Citation
- LEUKEMIA RESEARCH, v.33, no.2, pp 315 - 320
- Pages
- 6
- Journal Title
- LEUKEMIA RESEARCH
- Volume
- 33
- Number
- 2
- Start Page
- 315
- End Page
- 320
- ISSN
- 0145-2126
1873-5835
- Abstract
- Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor. little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess Whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and. moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production. (C) 2008 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.