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Serum BAFF expression in patients with myasthenia gravis
- Authors
- Kim, Jee Young; Yang, Young; Moon, Joon-Shik; Lee, Eun Young; So, Sun Hwha; Lee, Hong-Soo; Park, Kee Duk; Choi, Young-Chul
- Issue Date
- Aug-2008
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- BAFF; B lymphocyte stimulator; myasthenia gravis (MG)
- Citation
- JOURNAL OF NEUROIMMUNOLOGY, v.199, no.1-2, pp 151 - 154
- Pages
- 4
- Journal Title
- JOURNAL OF NEUROIMMUNOLOGY
- Volume
- 199
- Number
- 1-2
- Start Page
- 151
- End Page
- 154
- ISSN
- 0165-5728
1872-8421
- Abstract
- A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patients with those of 30 healthy controls. Serum BAFF levels of MG group Were significantly higher than those of healthy group. These results suggested that the BAFF might play a role in the immunopathogenesis of MG and further study on B-cell and T-cell activation may be needed. (C) 2008 Elsevier B.V. All rights reserved.
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