Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of Sedum sarmentosum extract
- Authors
- Jung, Hyun-Joo; Kang, Hyun-Jung; Song, Yun Seon; Park, Eun-Hee; Kim, Young-Myeong; Lim, Chang-Jin
- Issue Date
- 28-Feb-2008
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- anti-nociceptive; anti-angiogenic; anti-inflammatory; inducible nitric oxide synthase; nitric oxide; Sedum sarmentosum Bunge
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.116, no.1, pp 138 - 143
- Pages
- 6
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 116
- Number
- 1
- Start Page
- 138
- End Page
- 143
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14320
- DOI
- 10.1016/j.jep.2007.11.014
- ISSN
- 0378-8741
- Abstract
- This study aimed to assess some novel pharmacological activities of Sedum sarmentosum Bunge, a perennial herb widely distributed on the mountain slopes in Oriental countries and traditionally used for the treatment of certain inflammatory diseases. Sedum sarmentosum was extracted with absolute methanol to generate the methanol extract (SS). SS exhibited a significant inhibitory activity in the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner (IC50 = 2.29 mu g/egg). The anti-nociceptive activity of SS was demonstrated using acetic acid-induced writhing model in mice. SS reduced the levels of anti-inflammatory markers, such as volume of exudates, number of polymorphonuclear leukocytes and nitrite content, in the air pouch model. It dose-dependently exhibited an inhibitory activity in the acetic acid-induced vascular permeability in mice. It suppressed production of nitric oxide in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages. In brief, the results provide some pharmacological basis for the therapeutic use of Sedum sarmentosum. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.