Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro
- Authors
- Youn, Yu Na; Lim, Erang; Lee, Nari; Kim, Young Seop; Koo, Min Seon; Choi, Soon Young
- Issue Date
- Feb-2008
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- bone; medicinal plants; osteoclast; osteoclastogenesis; TRAP assay
- Citation
- GENES AND NUTRITION, v.2, no.4, pp 375 - 380
- Pages
- 6
- Journal Title
- GENES AND NUTRITION
- Volume
- 2
- Number
- 4
- Start Page
- 375
- End Page
- 380
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14354
- DOI
- 10.1007/s12263-007-0062-1
- ISSN
- 1555-8932
1865-3499
- Abstract
- Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kappa B ligand ( RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii, and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKL-induced osteoclast differentiation.
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