LPS의 파골세포 분화 유도에 미치는 PDE4 저해제의 증강효과The Effect of PDE4 Inhibitor on LPS-Induced Osteoclastogenesis
- Other Titles
- The Effect of PDE4 Inhibitor on LPS-Induced Osteoclastogenesis
- Authors
- 노아롱새미; 천링; 임미정
- Issue Date
- Feb-2008
- Publisher
- 대한약학회
- Keywords
- LPS; phosphodiesterase 4 inhibitor; osteoblast; osteoclast
- Citation
- 약 학 회 지, v.52, no.1, pp 43 - 47
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 52
- Number
- 1
- Start Page
- 43
- End Page
- 47
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14546
- ISSN
- 0377-9556
- Abstract
- To determine the regulatory roles of PDE4 inhibitor on LPS-induced osteoclastogenesis, we investigated the
effect of a PDE4 inhibitor on osteoclast formation in the presence of LPS. A specific PDE4 inhibitor, rolipram, increased
LPS-induced osteoclast formation in cocultures. To verify that whether rolipram acts indirectly on osteoblasts, we investigated
the TRANCE and COX-2 mRNA expression levels in osteoblasts. Treatment of rolipram increased the expression
of TRANCE and COX-2 mRNA in osteoblasts stimulated by LPS. On the contrary, rolipram did not augment the number
of osteoclasts differentiated from bone marrow cells by LPS. In conclusion, the stimulation of LPS-induced osteoclast formation
by the PDE4 inhibitor are attributable to its indirect effect on osteoblasts, not to their direct effect on bone marrowderived
osteoclast precursors.
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