Antioxidant and anti-nociceptive activities of Ulmus davidiana var. japonica
- Authors
- Jung H.-J.; Kang H.-J.; Song Y.S.; Lim C.-J.; Park E.-H.
- Issue Date
- Mar-2008
- Keywords
- Anti-inflammatory; Anti-nociceptive; Antioxidant; Nitric oxide; Reactive oxygen species; Ulmus davidiana var. japonica
- Citation
- Biomolecules and Therapeutics, v.16, no.1, pp 9 - 13
- Pages
- 5
- Journal Title
- Biomolecules and Therapeutics
- Volume
- 16
- Number
- 1
- Start Page
- 9
- End Page
- 13
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14556
- DOI
- 10.4062/biomolther.2008.16.1.009
- ISSN
- 1976-9148
2005-4483
- Abstract
- Some pharmacological activities of Ulmus davidiana var. japonica were evaluated using its methanol extract (UDE). An acute anti-inflammatory activity of UDE was assessed using carrageenan-induced hind paw edema in rats. UDE exhibited an antioxidant activity when assayed by a stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). Dose-dependent anti-nociceptive activity of UDE was assessed using the acetic acid-induced writhing test in mice. UDE was able to diminish the reactive oxygen species (ROS) level in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. UDE also suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the stimulated macrophages cells. Collectively, the results imply that U. davidiana var. japonica has antioxidant and anti-nociceptive activities in addition to anti-inflammatory activity.
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