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Emerging Phospholipid Nanobiomaterials for Biomedical Applications to Lab-on-a-Chip, Drug Delivery, and Cellular Engineering

Authors
Rahimnejad, MaedehRabiee, NavidAhmadi, SepidehJahangiri, SepidehSajadi, S. MohammadAkhavan, OmidSaeb, Mohammad RezaKwon, WoosungKim, MunguHahn, Sei Kwang
Issue Date
Dec-2021
Publisher
AMER CHEMICAL SOC
Keywords
nanobiomaterials; phospholipid; lab-on-a-chip; drug delivery; cellular engineering
Citation
ACS APPLIED BIO MATERIALS, v.4, no.12, pp 8110 - 8128
Pages
19
Journal Title
ACS APPLIED BIO MATERIALS
Volume
4
Number
12
Start Page
8110
End Page
8128
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/145975
DOI
10.1021/acsabm.1c00932
ISSN
2576-6422
Abstract
The design of advanced nanobiomaterials to improve analytical accuracy and therapeutic efficacy has become an important prerequisite for the development of innovative nanomedicines. Recently, phospholipid nanobiomaterials including 2-methacryloylox-yethyl phosphorylcholine (MPC) have attracted great attention with remarkable characteristics such as resistance to nonspecific protein adsorption and cell adhesion for various biomedical applications. Despite many recent reports, there is a lack of comprehensive review on the phospholipid nanobiomaterials from synthesis to diagnostic and therapeutic applications. Here, we review the synthesis and characterization of phospholipid nanobiomaterials focusing on MPC polymers and highlight their attractive potentials for applications in micro/nanofabricated fluidic devices, biosensors, lab-on-a-chip, drug delivery systems (DDSs), COVID-19 potential usages for early diagnosis and even treatment, and artificial extracellular matrix scaffolds for cellular engineering.
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