The organizer and its signaling in embryonic development
- Authors
- Kumar, Vijay; Park, Soochul; Lee, Unjoo; Kim, Jaebong
- Issue Date
- Dec-2021
- Publisher
- MDPI
- Keywords
- BMP signaling; Embryonic development; Germ layer specification; Nodal; Organizer; TGFβ/activin
- Citation
- Journal of Developmental Biology, v.9, no.4, pp 1 - 17
- Pages
- 17
- Journal Title
- Journal of Developmental Biology
- Volume
- 9
- Number
- 4
- Start Page
- 1
- End Page
- 17
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146075
- DOI
- 10.3390/jdb9040047
- ISSN
- 2221-3759
2221-3759
- Abstract
- Germ layer specification and axis formation are crucial events in embryonic development. The Spemann organizer regulates the early developmental processes by multiple regulatory mechanisms. This review focuses on the responsive signaling in organizer formation and how the organizer orchestrates the germ layer specification in vertebrates. Accumulated evidence indicates that the organizer influences embryonic development by dual signaling. Two parallel processes, the migration of the organizer’s cells, followed by the transcriptional activation/deactivation of target genes, and the diffusion of secreting molecules, collectively direct the early development. Finally, we take an in-depth look at active signaling that originates from the organizer and involves germ layer specification and patterning. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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